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Online Lectures on Bioinformatics


Algorithms for SP-optimal multiple alignments


  • a multiple alignment gives a stronger signal for sequence similarities than a pairwise alignment, i.e. in
    sequence assembly
    molecular modelling
    database search
    primer design
  • ambiguities in the alignment may be resolved by a multiple alignment
  • looking into the relationship between the sequences leads to reconstructing a phylogenetic tree (see next section)

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